Increased sequence conservation of domain repeats in prokaryotic proteins

Dan Reshef; Zohar Itzhaki; Ora Schueler-Furman

doi:10.1016/j.tig.2010.06.003

Increased sequence conservation of domain repeats in prokaryotic proteins

Dan Reshef, Zohar Itzhaki, Ora Schueler-Furman^*

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

Protein domain repeats within a protein sequence have been observed throughout all domains of life. Our analysis shows a significantly higher degree of sequence identity between repeated domains in prokaryotes compared to eukaryotes. We discuss this difference in the light of aggregation prevention, contribution to functional divergence and binding-related functions. We then address the possible underlying features that create and conserve domain repeats. Our findings provide a starting point for the identification of the fundamental principles that underlie this basic difference between eukaryotic and prokaryotic protein evolution.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Trends in Genetics
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/j.tig.2010.06.003
State	Published - Sep 2010

Bibliographical note

Funding Information:
We thank Liran Carmel for helpful suggestions, Ed Bayer for an introduction into the cohesin field, and the members of the O.S.F. laboratory for helpful discussions. This work was supported by the Israel Science Foundation founded by the Israel Academy of Science and Humanities (grant number 306/6).

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10.1016/j.tig.2010.06.003

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author = "Dan Reshef and Zohar Itzhaki and Ora Schueler-Furman",

note = "Funding Information: We thank Liran Carmel for helpful suggestions, Ed Bayer for an introduction into the cohesin field, and the members of the O.S.F. laboratory for helpful discussions. This work was supported by the Israel Science Foundation founded by the Israel Academy of Science and Humanities (grant number 306/6). ",

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Increased sequence conservation of domain repeats in prokaryotic proteins

Abstract

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