Increased serum leptin and insulin concentrations in canine hypothyroidism

Michal Mazaki-Tovi*, Yonatan Feuermann, Gilad Segev, Eyal Klement, Einat Yas-Natan, Amnon Farkas, Amir Kol, Avi Shamay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Serum concentrations of leptin and insulin were compared between gender-matched hypothyroid (n = 25) and healthy (n = 25) client-owned dogs within comparable age and body condition score (BCS) ranges. Fasted blood samples were collected from each dog and analysed for glucose, cholesterol, triglyceride, leptin and insulin concentrations. Leptin and insulin concentrations were significantly higher in the hypothyroid compared to normal dogs (P = 0.006 and P = 0.001, respectively) following adjustment for potential confounders. A nearly significant (P = 0.051) interaction with BCS was found in the association between hypothyroidism and leptin. Leptin concentrations were significantly higher in hypothyroid dogs compared to normal dogs, in separate analyses for BCS 6 (P = 0.036) and 7 (P = 0.049). There was no significant difference in glucose concentration between the hypothyroid and normal groups (P = 0.84) following adjustment for BCS. This study showed that canine hypothyroidism is associated with increased serum leptin and insulin concentrations, neither of which may be attributed to obesity alone.

Original languageAmerican English
Pages (from-to)109-114
Number of pages6
JournalVeterinary Journal
Issue number1
StatePublished - Jan 2010

Bibliographical note

Funding Information:
The study was supported by a grant from the Clinical Studies Fund of the Veterinary Teaching Hospital, The Hebrew University of Jerusalem.


  • Dog
  • Hypothyroidism
  • Insulin
  • Leptin
  • Obesity


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