Indexing molecules for their hERG liability

Pharmacology, Toxicology and Pharmaceutical Science

• Drug Discovery 100%
• Potassium Channel 100%
• Elimination 50%
• Heart Arrhythmia 50%
• Potassium Ion 50%
• Isotopes of Potassium 50%
• Sudden Cardiac Death 50%
• Potassium Channel HERG 50%
• Critical Micelle Concentration 50%
• Potassium 50%

Keyphrases

• HERG 100%
• Gene Toxicity 30%
• Beta-blockers 20%
• Drug Candidates 20%
• K Channels 20%
• Drug pipeline 20%
• Toxicity Index 20%
• Area under the Curve 10%
• Blockage 10%
• Excellent Performance 10%
• Computational Model 10%
• Binding Affinity 10%
• Drug Binding 10%
• Arrhythmia 10%
• Iterative Stochastic Elimination 10%
• Binder 10%
• Early Prediction 10%
• Endogenous Substances 10%
• Potassium Channel 10%
• In Vitro Assessment 10%
• Cardiac Action Potential 10%
• Pharmaceutical Products 10%
• QT Interval 10%
• Lead Optimization 10%
• Elimination Algorithm 10%
• Index Model 10%
• Sudden Cardiac Death 10%
• Rule-based Model 10%
• Matthews Correlation Coefficient 10%
• Proposed Strategy 10%
• External Test 10%