Indomethacin modulates plasma membrane-associated properties of macrophages

E. Razin; A. Globerson; E. Skutelsky

doi:10.1016/0262-1746(82)90053-1

Indomethacin modulates plasma membrane-associated properties of macrophages

E. Razin
, A. Globerson^*
, E. Skutelsky

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Changes in the plasma membrane of macrophages treated with indomethacin were investigated. A significant decrease in the binding of IgG was observed with indomethacin-treated cells, as compared to the control group. Electron microscopic examination did not show any significant morphological differences between the indomethacin treated macrophages and the controls. It was found, however, that indomethacin treatment resulted in a drastic increase in the binding capactiy of the cell membrane to cationized ferritin. It is suggested that indomethacin may have a modulating effect on the macrophage plasma membrane.

Original language	English
Pages (from-to)	301-310
Number of pages	10
Journal	Prostaglandins Leukotrienes and Medicine
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0262-1746(82)90053-1
State	Published - Apr 1982
Externally published	Yes

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title = "Indomethacin modulates plasma membrane-associated properties of macrophages",

abstract = "Changes in the plasma membrane of macrophages treated with indomethacin were investigated. A significant decrease in the binding of IgG was observed with indomethacin-treated cells, as compared to the control group. Electron microscopic examination did not show any significant morphological differences between the indomethacin treated macrophages and the controls. It was found, however, that indomethacin treatment resulted in a drastic increase in the binding capactiy of the cell membrane to cationized ferritin. It is suggested that indomethacin may have a modulating effect on the macrophage plasma membrane.",

author = "E. Razin and A. Globerson and E. Skutelsky",

year = "1982",

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AU - Globerson, A.

AU - Skutelsky, E.

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N2 - Changes in the plasma membrane of macrophages treated with indomethacin were investigated. A significant decrease in the binding of IgG was observed with indomethacin-treated cells, as compared to the control group. Electron microscopic examination did not show any significant morphological differences between the indomethacin treated macrophages and the controls. It was found, however, that indomethacin treatment resulted in a drastic increase in the binding capactiy of the cell membrane to cationized ferritin. It is suggested that indomethacin may have a modulating effect on the macrophage plasma membrane.

AB - Changes in the plasma membrane of macrophages treated with indomethacin were investigated. A significant decrease in the binding of IgG was observed with indomethacin-treated cells, as compared to the control group. Electron microscopic examination did not show any significant morphological differences between the indomethacin treated macrophages and the controls. It was found, however, that indomethacin treatment resulted in a drastic increase in the binding capactiy of the cell membrane to cationized ferritin. It is suggested that indomethacin may have a modulating effect on the macrophage plasma membrane.

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Indomethacin modulates plasma membrane-associated properties of macrophages

Abstract

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