Induced mutation in the SiALS gene offers new weed management opportunities for sesame crop

Yaron Gadri, Asaf Avneri, Zvi Peleg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Weeds are the primary biotic constraint affecting sesame growth and production. Here, we applied EMS mutagenesis to an elite sesame cultivar and discovered a novel point mutation in the sesame SiALS gene conferring resistance to imidazolinone, a group of acetolactate-synthase (ALS)-inhibitors. The mutant line exhibited high resistance to imazamox, an ALS-inhibitor, with hybrid plants displaying an intermediate response. Field-based validation confirmed the mutant line's substantial resistance, leading to a significantly higher yield under imazamox treatment. Under pre-emergence application of imazapic, the mutant plants sustained growth, whereas wild-type and weed were effectively controlled. Field trials using s-metolachlor and imazapic combined resulted in weed-free plots compared to untreated controls. Consequently, this treatment showed a significantly greater yield (2280 vs. 880 Kg ha−1) than the commercial practice (s-metolachlor). Overall, our study unveils the potential of utilizing this point mutation in sesame breeding programs, offering new opportunities for integrated weed management strategies for sesame cultivation. Developing herbicide-resistant crop plants holds promise for supporting sustainable production and addressing the challenges of weed infestations in sesame farming.

Original languageAmerican English
Article number112104
JournalPlant Science
StatePublished - Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier B.V.


  • ALS-inhibiting herbicide
  • Herbicide-resistant crops
  • Integrated weed management
  • Mutagenesis


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