Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

Ruth Brandes; Rivka Arad; Jacob Bar-Tana

doi:10.1016/0006-2952(95)02082-9

Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

Ruth Brandes, Rivka Arad, Jacob Bar-Tana^*

^*Corresponding author for this work

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.

Original language	English
Pages (from-to)	1949-1951
Number of pages	3
Journal	Biochemical Pharmacology
Volume	50
Issue number	11
DOIs	https://doi.org/10.1016/0006-2952(95)02082-9
State	Published - 27 Nov 1995

Keywords

adipose conversion
fatty acids
peroxisome proliferators activated receptors

Access to Document

10.1016/0006-2952(95)02082-9

Cite this

@article{63dfdcd4cc57467db8041b820f7f3438,

title = "Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells",

abstract = "Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.",

keywords = "adipose conversion, fatty acids, peroxisome proliferators activated receptors",

author = "Ruth Brandes and Rivka Arad and Jacob Bar-Tana",

year = "1995",

month = nov,

day = "27",

doi = "10.1016/0006-2952(95)02082-9",

language = "אנגלית",

volume = "50",

pages = "1949--1951",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Inc.",

number = "11",

}

TY - JOUR

T1 - Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

AU - Brandes, Ruth

AU - Arad, Rivka

AU - Bar-Tana, Jacob

PY - 1995/11/27

Y1 - 1995/11/27

N2 - Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.

AB - Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.

KW - adipose conversion

KW - fatty acids

KW - peroxisome proliferators activated receptors

UR - http://www.scopus.com/inward/record.url?scp=0029587176&partnerID=8YFLogxK

U2 - 10.1016/0006-2952(95)02082-9

DO - 10.1016/0006-2952(95)02082-9

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 8615877

AN - SCOPUS:0029587176

SN - 0006-2952

VL - 50

SP - 1949

EP - 1951

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 11

ER -

Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this