Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

Ruth Brandes; Rivka Arad; Jacob Bar-Tana

doi:10.1016/0006-2952(95)02082-9

Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

Ruth Brandes, Rivka Arad, Jacob Bar-Tana^*

^*Corresponding author for this work

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.

Original language	English
Pages (from-to)	1949-1951
Number of pages	3
Journal	Biochemical Pharmacology
Volume	50
Issue number	11
DOIs	https://doi.org/10.1016/0006-2952(95)02082-9
State	Published - 27 Nov 1995

Keywords

adipose conversion
fatty acids
peroxisome proliferators activated receptors

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10.1016/0006-2952(95)02082-9

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title = "Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells",

abstract = "Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.",

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AU - Brandes, Ruth

AU - Arad, Rivka

AU - Bar-Tana, Jacob

PY - 1995/11/27

Y1 - 1995/11/27

N2 - Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.

AB - Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.

KW - adipose conversion

KW - fatty acids

KW - peroxisome proliferators activated receptors

UR - https://www.scopus.com/pages/publications/0029587176

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JO - Biochemical Pharmacology

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IS - 11

ER -

Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

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