Inducing Gamma Oscillations and Precise Spike Synchrony by Operant Conditioning via Brain-Machine Interface

Ben Engelhard*, Nofar Ozeri, Zvi Israel, Hagai Bergman, Eilon Vaadia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Neural oscillations in the low-gamma range (30-50 Hz) have been implicated in neuronal synchrony, computation, behavior, and cognition. Abnormal low-gamma activity, hypothesized to reflect impaired synchronization, has been evidenced in several brain disorders. Thus, understanding the relations between gamma oscillations, neuronal synchrony and behavior is a major research challenge. We used a brain-machine interface (BMI) to train monkeys to specifically increase low-gamma power in selected sites of motor cortex to move a cursor and obtain a reward. The monkeys learned to robustly generate oscillatory gamma waves, which were accompanied by a dramatic increase of spiking synchrony of highly precise spatiotemporal patterns. The findings link volitional control of LFP oscillations, neuronal synchrony, and the behavioral outcome. Subjects@ ability to directly modulate specific patterns of neuronal synchrony provides a powerful approach for understanding neuronal processing in relation to behavior and for the use of BMIs in a clinical setting.

Original languageAmerican English
Pages (from-to)361-375
Number of pages15
JournalNeuron
Volume77
Issue number2
DOIs
StatePublished - 23 Jan 2013

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