Induction by soluble factors of organized axial structures in chick epiblasts

Eduardo Mitrani*, Yael Shimoni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Inductive action of soluble factors was tested on isolated chick epiblasts. An assay was developed wherein conditioned medium derived from the Xenopus XTC cell line induced the formation of a full-length notochord and rows of bilaterally symmetric somites. Basic fibroblast growth factor, epidermal growth factor, retinoic acid, and transforming growth factor type β1 and β2 were not capable of inducing axial structures. Thus, soluble factors can elicit the development of polarity stored in the epiblast and behave as true morphogens since they can induce the formation of the organized complex structures that constitute the embryonic axis.

Original languageEnglish
Pages (from-to)1092-1094
Number of pages3
JournalScience
Volume247
Issue number4946
DOIs
StatePublished - 1990

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