TY - JOUR
T1 - Induction of immune responsiveness in a genetically low‐responsive tumor‐host combination by chemical modification of the immunogen
AU - Galili, Naomi
AU - Naor, D.
AU - Åsjö, Birgitta
AU - Klein, G.
PY - 1976/7
Y1 - 1976/7
N2 - Trinitrophenylated Moloney virus‐induced YAC cells induced a higher cytotoxic antibody response and better protection against small tumor cell doses in syngeneic, low‐responsive strain A mice than nonmodified YAC cells that had been inactivated by irradiation or mitomycin C treatment. The results indicated that genetically determined low responsiveness to a virally induced antigen can be overcome, at least to some extent, by coupling the immunizing cells to a strong immunogenic hapten.
AB - Trinitrophenylated Moloney virus‐induced YAC cells induced a higher cytotoxic antibody response and better protection against small tumor cell doses in syngeneic, low‐responsive strain A mice than nonmodified YAC cells that had been inactivated by irradiation or mitomycin C treatment. The results indicated that genetically determined low responsiveness to a virally induced antigen can be overcome, at least to some extent, by coupling the immunizing cells to a strong immunogenic hapten.
UR - http://www.scopus.com/inward/record.url?scp=0017142968&partnerID=8YFLogxK
U2 - 10.1002/eji.1830060705
DO - 10.1002/eji.1830060705
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C2 - 991914
AN - SCOPUS:0017142968
SN - 0014-2980
VL - 6
SP - 473
EP - 476
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 7
ER -
