Abstract
Retinoic acid is reported here to induce peroxisomal β-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5'-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.
Original language | English |
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Pages (from-to) | 41-43 |
Number of pages | 3 |
Journal | Biochemical Journal |
Volume | 281 |
Issue number | 1 |
DOIs | |
State | Published - 1992 |