Induction of peroxisomal β-oxidation genes by retinoic acid in cultured rat hepatocytes

R. Hertz, J. Bar-Tana*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Retinoic acid is reported here to induce peroxisomal β-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5'-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalBiochemical Journal
Volume281
Issue number1
DOIs
StatePublished - 1992

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