Inflammation meets cancer, with NF-κB as the matchmaker

Yinon Ben-Neriah; Michael Karin

doi:10.1038/ni.2060

Inflammation meets cancer, with NF-κB as the matchmaker

Yinon Ben-Neriah^*
, Michael Karin

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Review article › peer-review

1321 Scopus citations

Abstract

Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.

Original language	English
Pages (from-to)	715-723
Number of pages	9
Journal	Nature Immunology
Volume	12
Issue number	8
DOIs	https://doi.org/10.1038/ni.2060
State	Published - Aug 2011

Bibliographical note

Funding Information:
We thank E. Pikarsky, I. Alkalay-Snir and A. Pribluda for comments and discussions. Supported by the Israel Science Foundation, Israel Cancer Research Fund, the Crohn’s & Colitis Foundation of America, the German-Israeli Foundation, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, the US National Institutes of Health and the American Cancer Society.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/ni.2060

Cite this

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abstract = "Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.",

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Inflammation meets cancer, with NF-κB as the matchmaker

Abstract

Bibliographical note

UN SDGs

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