Inflammatory networks underlying colorectal cancer

Audrey Lasry, Adar Zinger, Yinon Ben-Neriah*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

394 Scopus citations

Abstract

Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors remains unclear. Whereas a minority of solid tumors are associated with overt inflammation, long-term treatment with non-steroidal anti-inflammatory drugs is remarkably effective in reducing cancer rate and death. This indicates that inflammation might have many as-yet-unrecognized facets, among which an indolent course might be far more prevalent than previously appreciated. In this Review, we explore the various inflammatory processes underlying the development and progression of colorectal cancer and discuss anti-inflammatory means for its prevention and treatment.

Original languageAmerican English
Pages (from-to)230-240
Number of pages11
JournalNature Immunology
Volume17
Issue number3
DOIs
StatePublished - 16 Feb 2016

Bibliographical note

Funding Information:
Supported by Israeli Science Foundation Centers of Excellence, the European Research Council Framework Programme 7 (294390 PICHO), The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, the I-CORE program of the Israel Science Foundation (41/11) and the Israel Cancer Research Fund (Y.B.-N.).

Publisher Copyright:
© 2016 Nature America, Inc. All rights reserved.

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