Influence of ethnicity and improved outcome of acute myeloid leukaemia: Two decades of follow-up of Israeli patient cohort

Neta Goldschmidt; Sara B. Cohen; Moshe E. Gatt; Myriam Safrai; Deborah Rund

doi:10.1002/hon.2092

Influence of ethnicity and improved outcome of acute myeloid leukaemia: Two decades of follow-up of Israeli patient cohort

Neta Goldschmidt^*, Sara B. Cohen, Moshe E. Gatt, Myriam Safrai, Deborah Rund

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Acute myeloid leukaemia is a disease with unfavourable prognosis. The significance of various prognostic parameters is not fully understood. We studied 293 patients to examine the influence of ethnicity and molecular markers. The median survival for all patients was correlated with age, white blood cell count and karyotype, and marginally with FLT3 internal tandem duplication. Arab patients were younger than Jewish patients; however, their survival was poorer albeit being treated with the same protocols and having more favourable cytogenetics. Survival rates improved over time but only for patients undergoing allogeneic bone marrow transplantation (alloBMT). We conclude that in our young patient cohort, recent improvement in survival is attributed to alloBMT therapy and that ethnicity affected treatment outcome.

Original language	English
Pages (from-to)	94-101
Number of pages	8
Journal	Hematological Oncology
Volume	32
Issue number	2
DOIs	https://doi.org/10.1002/hon.2092
State	Published - Jun 2014
Externally published	Yes

Keywords

Acute myeloid leukaemia
Age
Bone marrow transplantation
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hon.2092

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abstract = "Acute myeloid leukaemia is a disease with unfavourable prognosis. The significance of various prognostic parameters is not fully understood. We studied 293 patients to examine the influence of ethnicity and molecular markers. The median survival for all patients was correlated with age, white blood cell count and karyotype, and marginally with FLT3 internal tandem duplication. Arab patients were younger than Jewish patients; however, their survival was poorer albeit being treated with the same protocols and having more favourable cytogenetics. Survival rates improved over time but only for patients undergoing allogeneic bone marrow transplantation (alloBMT). We conclude that in our young patient cohort, recent improvement in survival is attributed to alloBMT therapy and that ethnicity affected treatment outcome.",

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AU - Safrai, Myriam

AU - Rund, Deborah

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Influence of ethnicity and improved outcome of acute myeloid leukaemia: Two decades of follow-up of Israeli patient cohort

Abstract

Keywords

UN SDGs

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