Influence of ethnicity and improved outcome of acute myeloid leukaemia: Two decades of follow-up of Israeli patient cohort

Neta Goldschmidt*, Sara B. Cohen, Moshe E. Gatt, Myriam Safrai, Deborah Rund

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Acute myeloid leukaemia is a disease with unfavourable prognosis. The significance of various prognostic parameters is not fully understood. We studied 293 patients to examine the influence of ethnicity and molecular markers. The median survival for all patients was correlated with age, white blood cell count and karyotype, and marginally with FLT3 internal tandem duplication. Arab patients were younger than Jewish patients; however, their survival was poorer albeit being treated with the same protocols and having more favourable cytogenetics. Survival rates improved over time but only for patients undergoing allogeneic bone marrow transplantation (alloBMT). We conclude that in our young patient cohort, recent improvement in survival is attributed to alloBMT therapy and that ethnicity affected treatment outcome.

Original languageAmerican English
Pages (from-to)94-101
Number of pages8
JournalHematological Oncology
Volume32
Issue number2
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • Acute myeloid leukaemia
  • Age
  • Bone marrow transplantation
  • Prognosis

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