Influence of hypothalamic deposits of antidipsic drugs on renal excretion

Y. Gutman; F. Bergmann; A. Zerchia

doi:10.1016/0014-2999(71)90222-6

Influence of hypothalamic deposits of antidipsic drugs on renal excretion

Y. Gutman^*
, F. Bergmann
, A. Zerchia

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Antidipsic drugs, implanted bilaterally into the rat hypothalamus affected urine excretion. Urine volume was augmented and the osmolarity lowered, as compared to controls with hypothalamic talc deposits and deprived of water. The possibility that both effects, adipsia and polyuria, may result from inhibition of hypothalamic osmoreceptor function is discussed.

Original language	English
Pages (from-to)	326-329
Number of pages	4
Journal	European Journal of Pharmacology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(71)90222-6
State	Published - Feb 1971

Keywords

Adipsia
Ethacrynic acid
Hypothalamic implantation
Mercuric acetate
Phenformin
Polyuria

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10.1016/0014-2999(71)90222-6

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abstract = "Antidipsic drugs, implanted bilaterally into the rat hypothalamus affected urine excretion. Urine volume was augmented and the osmolarity lowered, as compared to controls with hypothalamic talc deposits and deprived of water. The possibility that both effects, adipsia and polyuria, may result from inhibition of hypothalamic osmoreceptor function is discussed.",

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AU - Bergmann, F.

AU - Zerchia, A.

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AB - Antidipsic drugs, implanted bilaterally into the rat hypothalamus affected urine excretion. Urine volume was augmented and the osmolarity lowered, as compared to controls with hypothalamic talc deposits and deprived of water. The possibility that both effects, adipsia and polyuria, may result from inhibition of hypothalamic osmoreceptor function is discussed.

KW - Adipsia

KW - Ethacrynic acid

KW - Hypothalamic implantation

KW - Mercuric acetate

KW - Phenformin

KW - Polyuria

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ER -

Influence of hypothalamic deposits of antidipsic drugs on renal excretion

Abstract

Keywords

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