TY - JOUR
T1 - Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats
AU - Bergmann, Felix
AU - Lieblich, Israel
AU - Cohen, Edna
AU - Ganchrow, Judith R.
PY - 1985/11
Y1 - 1985/11
N2 - The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.
AB - The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.
UR - http://www.scopus.com/inward/record.url?scp=0022373469&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(85)90616-8
DO - 10.1016/S0163-1047(85)90616-8
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C2 - 4084181
AN - SCOPUS:0022373469
SN - 0163-1047
VL - 44
SP - 347
EP - 353
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 3
ER -