Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats

Felix Bergmann; Israel Lieblich; Edna Cohen; Judith R. Ganchrow

doi:10.1016/S0163-1047(85)90616-8

Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats

Felix Bergmann^*
, Israel Lieblich
, Edna Cohen
, Judith R. Ganchrow

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.

Original language	English
Pages (from-to)	347-353
Number of pages	7
Journal	Behavioral and Neural Biology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/S0163-1047(85)90616-8
State	Published - Nov 1985

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10.1016/S0163-1047(85)90616-8

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abstract = "The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3\% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.",

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AB - The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.

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Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats

Abstract

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