Influenza virus uses its neuraminidase protein to evade the recognition of two activating NK cell receptors

Yotam Bar-On, Einat Seidel, Pinchas Tsukerman, Michal Mandelboim, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Natural Killer (NK) cells play a central role in the defense against viral infections and in the elimination of transformed cells. The recognition of pathogen-infected and tumor cells is controlled by inhibitory and activating receptors.We have previously shown that among the activating (killer) NK cell receptors the natural cytotoxicity receptors, NKp44 and NKp46, interact with the viral hemagglutinin (HA) protein expressed on the cell surface of influenza-virus-infected cells.We further showed that the interaction between NKp44/NKp46 and viral HA is sialic-acid dependent and that the recognition of HA by NKp44 and NKp46 leads to the elimination of the infected cells. Here we demonstrate that the influenza virus developed a counter-attack mechanism and that the virus uses its neuraminidase (NA) protein to prevent the recognition of HA by both the NKp44 and NKp46 receptors, resulting in reduced elimination of the infected cells by NK cells.

Original languageAmerican English
Pages (from-to)410-418
Number of pages9
JournalJournal of Infectious Diseases
Volume210
Issue number3
DOIs
StatePublished - 1 Aug 2014

Keywords

  • Immune evasion
  • Influenza virus
  • NK cells
  • NKp44
  • NKp46
  • Neuraminidase

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