Abstract
Blood monocytes develop in the bone marrow before being released into the peripheral circulation. The circulating monocyte pool is composed of multiple subsets, each with specialized functions. These cells are recruited to repopulate resident monocyte-derived cells in the periphery and also to sites of injury. Several extrinsic factors influence the function and quantity of monocytes in the blood. Here, we outline the impact of sex, ethnicity, age, sleep, diet, and exercise on monocyte subsets and their function, highlighting that steady state is not a single physiological condition. A clearer understanding of the relationship between these factors and the immune system may allow for improved therapeutic strategies.
| Original language | American English |
|---|---|
| Article number | 2581 |
| Journal | Frontiers in Immunology |
| Volume | 10 |
| DOIs | |
| State | Published - 7 Nov 2019 |
Bibliographical note
Funding Information:We apologize to our colleagues whose work we were unable to cite due to space restrictions. Funding. AP was supported by an EPSRC studentship.
Publisher Copyright:
© Copyright © 2019 Patel and Yona.
Keywords
- age
- diet
- exercise
- inflammation
- macrophage
- monocyte
- sex
- sleep