Inherited propensity for neuropathic pain is mediated by sensitivity to injury discharge

Sergiu Cohn, Ze'ev Seltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We reported previously that injury discharge (ID), a burst of impulses fired following nerve injury, plays a role in triggering autotomy, a neuropathic pain-related behavior in rats. Here we affirm this link using two lines of rats, derived by selective breeding from the Sabra strain to express high (HA) or low (LA) levels of autotomy following hindpaw denervation. Blocking ID in HA rats before injury suppressed autotomy. Correspondingly, artificial prolongation of ID in LA rats just prior to neurectomy, increased autotomy. The autotomy in these HA and LA rats was like that of their Sabra ancestors. This suggests that the underlying basis for selection of these lines was differential sensitivity of the CNS to the effects of ID.

Original languageEnglish
Pages (from-to)647-650
Number of pages4
JournalNeuroReport
Volume2
Issue number11
DOIs
StatePublished - Nov 1991

Keywords

  • Autotomy
  • Genetic selection
  • HA rats
  • Injury discharge
  • LA rats
  • Nerve block
  • Neuropathic pain

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