Inhibition of arachidonic acid oxidation by β-carotene, retinol and α-tocopherol

Orna Halevy; David Sklan

doi:10.1016/0005-2760(87)90235-9

Inhibition of arachidonic acid oxidation by β-carotene, retinol and α-tocopherol

Orna Halevy, David Sklan^*

^*Corresponding author for this work

Department of Animal Sciences

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Prostaglandin and hydroxyicosatetraenoic acid (HETE) production from arachidonic acid in bovine seminal vesicles and kidney as influenced by the addition of β-carotene, retinol or α-tocopherol was studied. The major product formed was prostaglandin E₂ (approximately 85% prostaglandin E₂ of control), and its proportion decreased with increasing concentration of the additives, while the proportion of HETE increased. Prostaglandin and HETE production was considerably inhibited by β-carotene and retinol, and to a lesser extent by α-tocopherol; HETE production was inhibited less than that of prostaglandin. It appears that β-carotene, retinol and α-tocopherol influence both the cyclooxygenase and lipoxygenase pathways; this modulation of arachidonic acid oxidation by physiological compounds may have important in vivo implications.

Original language	English
Pages (from-to)	304-307
Number of pages	4
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	918
Issue number	3
DOIs	https://doi.org/10.1016/0005-2760(87)90235-9
State	Published - 24 Apr 1987

Keywords

Arachidonate oxidation
Hydroxyicosatetraenoic acid
Prostaglandin
α-Tocopherol
β-Carotene

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10.1016/0005-2760(87)90235-9

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title = "Inhibition of arachidonic acid oxidation by β-carotene, retinol and α-tocopherol",

abstract = "Prostaglandin and hydroxyicosatetraenoic acid (HETE) production from arachidonic acid in bovine seminal vesicles and kidney as influenced by the addition of β-carotene, retinol or α-tocopherol was studied. The major product formed was prostaglandin E2 (approximately 85% prostaglandin E2 of control), and its proportion decreased with increasing concentration of the additives, while the proportion of HETE increased. Prostaglandin and HETE production was considerably inhibited by β-carotene and retinol, and to a lesser extent by α-tocopherol; HETE production was inhibited less than that of prostaglandin. It appears that β-carotene, retinol and α-tocopherol influence both the cyclooxygenase and lipoxygenase pathways; this modulation of arachidonic acid oxidation by physiological compounds may have important in vivo implications.",

keywords = "Arachidonate oxidation, Hydroxyicosatetraenoic acid, Prostaglandin, α-Tocopherol, β-Carotene",

author = "Orna Halevy and David Sklan",

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AU - Sklan, David

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N2 - Prostaglandin and hydroxyicosatetraenoic acid (HETE) production from arachidonic acid in bovine seminal vesicles and kidney as influenced by the addition of β-carotene, retinol or α-tocopherol was studied. The major product formed was prostaglandin E2 (approximately 85% prostaglandin E2 of control), and its proportion decreased with increasing concentration of the additives, while the proportion of HETE increased. Prostaglandin and HETE production was considerably inhibited by β-carotene and retinol, and to a lesser extent by α-tocopherol; HETE production was inhibited less than that of prostaglandin. It appears that β-carotene, retinol and α-tocopherol influence both the cyclooxygenase and lipoxygenase pathways; this modulation of arachidonic acid oxidation by physiological compounds may have important in vivo implications.

AB - Prostaglandin and hydroxyicosatetraenoic acid (HETE) production from arachidonic acid in bovine seminal vesicles and kidney as influenced by the addition of β-carotene, retinol or α-tocopherol was studied. The major product formed was prostaglandin E2 (approximately 85% prostaglandin E2 of control), and its proportion decreased with increasing concentration of the additives, while the proportion of HETE increased. Prostaglandin and HETE production was considerably inhibited by β-carotene and retinol, and to a lesser extent by α-tocopherol; HETE production was inhibited less than that of prostaglandin. It appears that β-carotene, retinol and α-tocopherol influence both the cyclooxygenase and lipoxygenase pathways; this modulation of arachidonic acid oxidation by physiological compounds may have important in vivo implications.

KW - Arachidonate oxidation

KW - Hydroxyicosatetraenoic acid

KW - Prostaglandin

KW - α-Tocopherol

KW - β-Carotene

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Inhibition of arachidonic acid oxidation by β-carotene, retinol and α-tocopherol

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