TY - JOUR
T1 - Inhibition of calcium oxalate crystallization by glutamic acid
T2 - Different effects at low and high concentrations
AU - Azoury, Reuven
AU - Randolph, Alan D.
AU - Drach, George W.
AU - Perlberg, Saul
AU - Garti, Nissim
AU - Sarig, Sara
PY - 1983/11
Y1 - 1983/11
N2 - The effects of L-aspartic acid, alanine and L-glutamic acid on the crystallization of calcium oxalate were followed by two methods: measurements of the changes in calcium ion concentrations and determination of crystal size distribution in the calcium oxalate precipitate. The changes in calcium ion concentration were detected by a specific calcium electrode and are expressed as Discriminating Index (DI) values. Median size and number of crystals per milliliter were determined by Particle Data Counter. Glutamic acid in the range of 0-200 ppm was added to solutions of CaCl2 which were subsequently mixed with solutions of Na2C2O4 to yield CaC2O4 precipitation. At relatively high concentrations of glutamic acid, namely 20-200 ppm, the precipitation of calcium oxalate is retarded. However, at low concentrations, 2.5-20 ppm oxalate precipitation is enhanced. The two independent methods yield well-correlated results. Both L-aspartic acid and alanine did not affect the precipitation of calcium oxalate at similar experimental conditions.
AB - The effects of L-aspartic acid, alanine and L-glutamic acid on the crystallization of calcium oxalate were followed by two methods: measurements of the changes in calcium ion concentrations and determination of crystal size distribution in the calcium oxalate precipitate. The changes in calcium ion concentration were detected by a specific calcium electrode and are expressed as Discriminating Index (DI) values. Median size and number of crystals per milliliter were determined by Particle Data Counter. Glutamic acid in the range of 0-200 ppm was added to solutions of CaCl2 which were subsequently mixed with solutions of Na2C2O4 to yield CaC2O4 precipitation. At relatively high concentrations of glutamic acid, namely 20-200 ppm, the precipitation of calcium oxalate is retarded. However, at low concentrations, 2.5-20 ppm oxalate precipitation is enhanced. The two independent methods yield well-correlated results. Both L-aspartic acid and alanine did not affect the precipitation of calcium oxalate at similar experimental conditions.
UR - http://www.scopus.com/inward/record.url?scp=5644298153&partnerID=8YFLogxK
U2 - 10.1016/0022-0248(83)90148-3
DO - 10.1016/0022-0248(83)90148-3
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AN - SCOPUS:5644298153
SN - 0022-0248
VL - 64
SP - 389
EP - 392
JO - Journal of Crystal Growth
JF - Journal of Crystal Growth
IS - 2
ER -