Abstract
The kinetics of the inhibition of the catalatic reaction by cyanide is investigated. The inhibition is formally competitive. Cyanide can combine with both the free enzyme and the active enzyme substrate complex, the latter combination being more labile. The dissociation constant of the enzyme‐substrate‐inhibitor complex for horse liver catalase has been calculated from spectrophotometric data: Ki+ = 14 ± 4 μM. The agreement with the value calculated from kinetic data by Beers for horse blood catalase is satisfactory.
Original language | English |
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Pages (from-to) | 799-807 |
Number of pages | 9 |
Journal | Israel Journal of Chemistry |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - 1970 |