Inhibition of Catalase by Cyanide

M. L. Kremer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The kinetics of the inhibition of the catalatic reaction by cyanide is investigated. The inhibition is formally competitive. Cyanide can combine with both the free enzyme and the active enzyme substrate complex, the latter combination being more labile. The dissociation constant of the enzyme‐substrate‐inhibitor complex for horse liver catalase has been calculated from spectrophotometric data: Ki+ = 14 ± 4 μM. The agreement with the value calculated from kinetic data by Beers for horse blood catalase is satisfactory.

Original languageEnglish
Pages (from-to)799-807
Number of pages9
JournalIsrael Journal of Chemistry
Volume8
Issue number5
DOIs
StatePublished - 1970

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