Abstract
Pretreatment with the P3HR-1 substrain of Epstein-Barr virus (EBV) in-hibited approximately 85% of the DNA stimulation induced by Staphylococcus aureus in human B lymphocytes. In parallel experiments, the DNA stimulation induced by the trans-forming B95-8 substrain of EBV was almost completely inhibited by prior exposure to P3HR-1 virus. Phytohemagglutinin stimulation was only slightly inhibited, whereas the DNA synthesis of continuously growing Raji cells was inhibited to a considerable extent. The degree of DNA inhibition was correlated with the induction of the EBV-determined antigens (membrane, early, and nuclear antigens) in sensitive indicator cells.
| Original language | English |
|---|---|
| Pages (from-to) | 125-131 |
| Number of pages | 7 |
| Journal | Intervirology |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1978 |
| Externally published | Yes |
Keywords
- B-cell DNA synthesis
- Epstein-Barr virus
- Inhibition
- P3HR-I strain
- Staphylococcus aureus sti-mulation
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