Inhibition of fatty acid synthetases by the antibiotic cerulenin

D. Vance; I. Goldberg; O. Mitsuhashi; K. Bloch; Satoshi Omura; Setsuzo Nomura

doi:10.1016/0006-291X(72)90397-X

Inhibition of fatty acid synthetases by the antibiotic cerulenin

D. Vance^*
, I. Goldberg
, O. Mitsuhashi
, K. Bloch
, Satoshi Omura
, Setsuzo Nomura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

Abstract

The antibiotic cerulenin is a potent and apparently non-competitive inhibitor of fatty acid synthetase systems isolated from various microorganisms and from rat liver. Cerulenin specifically blocks the activity of β-keto acyl thioester synthetase (condensing enzyme). This effect may account for the inhibition of overall fatty acid synthesis by the antibiotic.

Original language	English
Pages (from-to)	649-656
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(72)90397-X
State	Published - 7 Aug 1972
Externally published	Yes

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10.1016/0006-291X(72)90397-X

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title = "Inhibition of fatty acid synthetases by the antibiotic cerulenin",

abstract = "The antibiotic cerulenin is a potent and apparently non-competitive inhibitor of fatty acid synthetase systems isolated from various microorganisms and from rat liver. Cerulenin specifically blocks the activity of β-keto acyl thioester synthetase (condensing enzyme). This effect may account for the inhibition of overall fatty acid synthesis by the antibiotic.",

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AU - Goldberg, I.

AU - Mitsuhashi, O.

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AU - Omura, Satoshi

AU - Nomura, Setsuzo

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AB - The antibiotic cerulenin is a potent and apparently non-competitive inhibitor of fatty acid synthetase systems isolated from various microorganisms and from rat liver. Cerulenin specifically blocks the activity of β-keto acyl thioester synthetase (condensing enzyme). This effect may account for the inhibition of overall fatty acid synthesis by the antibiotic.

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Inhibition of fatty acid synthetases by the antibiotic cerulenin

Abstract

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