Inhibition of herpesvirus deoxyribonucleic acid and protein synthesis by tilorone hydrochloride

E. Katz, E. Margalith, B. Winer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Tilorone hydrochloride at a concentration of 10 μg/ml very efficiently inhibited herpes simplex virus growth in BSC1 cells when the virus is infected at a low multiplicity of infection. The adsorption of the virus was not affected by the drug, and the penetration of the deoxyribonucleic acid of the input virus into the cytoplasm and nuclei proceeded normally when tilorone hydrochloride was present. However, newly synthesized viral deoxyribonucleic acid was not detectable under these conditions, there was a remarkable decrease in the rate of viral polypeptide synthesis, and virus particles were not formed. The inhibition of herpes virus growth by tilorone hydrochloride was absolutely dependent on the presence of the drug in the cultures. Pretreatment of the cells with the drug did not result in resistance to herpes virus infection after the removal of the drug.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume9
Issue number1
DOIs
StatePublished - 1976

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