Inhibition of membrane fusion by suppression of lateral movement of membrane proteins

David J. Volsky*, Abraham Loyter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Chicken erythrocytes were fused either by Sendai virus or by the combination of Ca2+ and ionophore A23187. Intramembrane particles and external anionic sites of cells undergoing fusion were found to acquire the ability to undergo a process of cold-induced clustering (thermotropic separation). Cationized ferritin (200 μg/ml 5% (v/v) cell suspension) inhibited both the fusion process and the thermotropic separation of intramembrane particles and external anionic sites. The correlation between the mobility of membrane proteins and the fusion process is discussed. It is suggested that an increase in the lateral mobility of membrane proteins is a prerequisite for initiation of membrane fusion.

Original languageEnglish
Pages (from-to)213-224
Number of pages12
JournalBiochimica et Biophysica Acta - Biomembranes
Volume514
Issue number2
DOIs
StatePublished - 19 Dec 1978

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