Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus

Marco A. Calzado; Katharina Schmid Lüdi; Bernd Fiebich; Yinon Ben-Neriah; Susanne Bacher; Eduardo Munoz; Mauro Ballero; Simona Prosperini; Giovanni Appendino; M. Lienhard Schmitz

doi:10.1016/j.bbaexp.2005.04.007

Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus

Marco A. Calzado
, Katharina Schmid Lüdi
, Bernd Fiebich
, Yinon Ben-Neriah
, Susanne Bacher
, Eduardo Munoz
, Mauro Ballero
, Simona Prosperini
, Giovanni Appendino
, M. Lienhard Schmitz^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Transcription factor NF-κB plays a key role for the inducible expression of genes mediating proinflammatory effects and is thus an important target for the development of antiinflammatory drugs. Here, we show that extracts from the plant Plagius flosculosus (L.) Alavi and Heyw. can inhibit the induction of NF-κB activity, and we describe the identification of three spiroketal compounds. Of those, only compound 1 could inhibit the phosphorylation and proteasomal degradation of IκB, thus preventing the nuclear import and DNA binding of NF-κB. Accordingly, compound 1, which is also found in the widely used medicinal herb chamomile, interfered with the LPS-induced production of IL-1, IL-6, TNF, and PGE2 in primary human monocytes.

Original language	English
Pages (from-to)	88-93
Number of pages	6
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1729
Issue number	2
DOIs	https://doi.org/10.1016/j.bbaexp.2005.04.007
State	Published - 30 Jun 2005

Bibliographical note

Funding Information:
This work was supported by a EU grant (AINP, contract QLK3-CT-2000-00463).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytokine
Inducible transcription
Inflammation
NF-κB

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10.1016/j.bbaexp.2005.04.007

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Calzado, M. A., Lüdi, K. S., Fiebich, B., Ben-Neriah, Y., Bacher, S., Munoz, E., Ballero, M., Prosperini, S., Appendino, G., & Schmitz, M. L. (2005). Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus. Biochimica et Biophysica Acta - Gene Structure and Expression, 1729(2), 88-93. https://doi.org/10.1016/j.bbaexp.2005.04.007

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title = "Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus",

abstract = "Transcription factor NF-κB plays a key role for the inducible expression of genes mediating proinflammatory effects and is thus an important target for the development of antiinflammatory drugs. Here, we show that extracts from the plant Plagius flosculosus (L.) Alavi and Heyw. can inhibit the induction of NF-κB activity, and we describe the identification of three spiroketal compounds. Of those, only compound 1 could inhibit the phosphorylation and proteasomal degradation of IκB, thus preventing the nuclear import and DNA binding of NF-κB. Accordingly, compound 1, which is also found in the widely used medicinal herb chamomile, interfered with the LPS-induced production of IL-1, IL-6, TNF, and PGE2 in primary human monocytes.",

keywords = "Cytokine, Inducible transcription, Inflammation, NF-κB",

author = "Calzado, \{Marco A.\} and L{\"u}di, \{Katharina Schmid\} and Bernd Fiebich and Yinon Ben-Neriah and Susanne Bacher and Eduardo Munoz and Mauro Ballero and Simona Prosperini and Giovanni Appendino and Schmitz, \{M. Lienhard\}",

note = "Funding Information: This work was supported by a EU grant (AINP, contract QLK3-CT-2000-00463).",

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Calzado, MA, Lüdi, KS, Fiebich, B, Ben-Neriah, Y, Bacher, S, Munoz, E, Ballero, M, Prosperini, S, Appendino, G & Schmitz, ML 2005, 'Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus', Biochimica et Biophysica Acta - Gene Structure and Expression, vol. 1729, no. 2, pp. 88-93. https://doi.org/10.1016/j.bbaexp.2005.04.007

Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus. / Calzado, Marco A.; Lüdi, Katharina Schmid; Fiebich, Bernd et al.
In: Biochimica et Biophysica Acta - Gene Structure and Expression, Vol. 1729, No. 2, 30.06.2005, p. 88-93.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus

AU - Calzado, Marco A.

AU - Lüdi, Katharina Schmid

AU - Fiebich, Bernd

AU - Ben-Neriah, Yinon

AU - Bacher, Susanne

AU - Munoz, Eduardo

AU - Ballero, Mauro

AU - Prosperini, Simona

AU - Appendino, Giovanni

AU - Schmitz, M. Lienhard

N1 - Funding Information: This work was supported by a EU grant (AINP, contract QLK3-CT-2000-00463).

PY - 2005/6/30

Y1 - 2005/6/30

N2 - Transcription factor NF-κB plays a key role for the inducible expression of genes mediating proinflammatory effects and is thus an important target for the development of antiinflammatory drugs. Here, we show that extracts from the plant Plagius flosculosus (L.) Alavi and Heyw. can inhibit the induction of NF-κB activity, and we describe the identification of three spiroketal compounds. Of those, only compound 1 could inhibit the phosphorylation and proteasomal degradation of IκB, thus preventing the nuclear import and DNA binding of NF-κB. Accordingly, compound 1, which is also found in the widely used medicinal herb chamomile, interfered with the LPS-induced production of IL-1, IL-6, TNF, and PGE2 in primary human monocytes.

AB - Transcription factor NF-κB plays a key role for the inducible expression of genes mediating proinflammatory effects and is thus an important target for the development of antiinflammatory drugs. Here, we show that extracts from the plant Plagius flosculosus (L.) Alavi and Heyw. can inhibit the induction of NF-κB activity, and we describe the identification of three spiroketal compounds. Of those, only compound 1 could inhibit the phosphorylation and proteasomal degradation of IκB, thus preventing the nuclear import and DNA binding of NF-κB. Accordingly, compound 1, which is also found in the widely used medicinal herb chamomile, interfered with the LPS-induced production of IL-1, IL-6, TNF, and PGE2 in primary human monocytes.

KW - Cytokine

KW - Inducible transcription

KW - Inflammation

KW - NF-κB

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JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

IS - 2

ER -

Inhibition of NF-κB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus

Abstract

Bibliographical note

UN SDGs

Keywords

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