Abstract
Cast films composed of ethyl cellulose and cetylpyridinium were prepared from an ethanol varnish and exhibited sustained inhibition of Streptococcus mutans growth in vitro. In a clinical study the varnish containing 2% of the drug was applied to removable appliances in 8 patients and the effect of sustained release of cetylpyridium on the total flora and on the plaque accumulation was measured. All oral hygiene procedures were withheld during the experiment. The results of the clinical study proved that a single application of cetylpyridinium varnish decreased plaque accumulation for a period of 3 days. No changes in the total salivary flora were observed during the study.
| Original language | English |
|---|---|
| Pages (from-to) | 243-247 |
| Number of pages | 5 |
| Journal | International Journal of Pharmaceutics |
| Volume | 44 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Jun 1988 |
Keywords
- Cetylpyridinium chloride
- Plaque prevention
- Sustained-release varnish