TY - JOUR
T1 - Inhibition of Plasmodium falciparum growth by a synthetic iron chelator
AU - Iheanacho, Eugene N.
AU - Samuni, Amram
AU - Avramovici-Grisaru, Schelly
AU - Sarel, Shalom
AU - Spira, Dan T.
PY - 1990/3
Y1 - 1990/3
N2 - The susceptibility of the chloroquine-resistant malaria parasite Plasmodium falciparum (FCR-3) to a pyridoxal-based iron chelator was tested. 10 μ m of the chelator 1 [n-ethoxycarbonylmethyl-pyridoxylidenium]-2-[2'-pyridyl] hydrazine bromide (code name L2-9) effectively inhibited growth in vitro of the parasites. Presaturation of the chelator with either ferric or ferrous iron partially blocked the inhibitory effect. Two hours' exposure of parasites to 20 L2-9 was sufficient to inhibit their growth irreversibly. Desferrioxamine blocked the inhibitory effect of L2-9. It is suggested that the chelator may be acting by generating free radicals in complexing intracellular iron.
AB - The susceptibility of the chloroquine-resistant malaria parasite Plasmodium falciparum (FCR-3) to a pyridoxal-based iron chelator was tested. 10 μ m of the chelator 1 [n-ethoxycarbonylmethyl-pyridoxylidenium]-2-[2'-pyridyl] hydrazine bromide (code name L2-9) effectively inhibited growth in vitro of the parasites. Presaturation of the chelator with either ferric or ferrous iron partially blocked the inhibitory effect. Two hours' exposure of parasites to 20 L2-9 was sufficient to inhibit their growth irreversibly. Desferrioxamine blocked the inhibitory effect of L2-9. It is suggested that the chelator may be acting by generating free radicals in complexing intracellular iron.
UR - http://www.scopus.com/inward/record.url?scp=0025375945&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(90)90259-H
DO - 10.1016/0035-9203(90)90259-H
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 2202102
AN - SCOPUS:0025375945
SN - 0035-9203
VL - 84
SP - 213
EP - 216
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 2
ER -