Inhibition of Plasmodium falciparum growth by a synthetic iron chelator

Eugene N. Iheanacho; Amram Samuni; Schelly Avramovici-Grisaru; Shalom Sarel; Dan T. Spira

doi:10.1016/0035-9203(90)90259-H

Inhibition of Plasmodium falciparum growth by a synthetic iron chelator

Eugene N. Iheanacho
, Amram Samuni
, Schelly Avramovici-Grisaru
, Shalom Sarel
, Dan T. Spira^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The susceptibility of the chloroquine-resistant malaria parasite Plasmodium falciparum (FCR-3) to a pyridoxal-based iron chelator was tested. 10 μ m of the chelator 1 [n-ethoxycarbonylmethyl-pyridoxylidenium]-2-[2'-pyridyl] hydrazine bromide (code name L2-9) effectively inhibited growth in vitro of the parasites. Presaturation of the chelator with either ferric or ferrous iron partially blocked the inhibitory effect. Two hours' exposure of parasites to 20 L2-9 was sufficient to inhibit their growth irreversibly. Desferrioxamine blocked the inhibitory effect of L2-9. It is suggested that the chelator may be acting by generating free radicals in complexing intracellular iron.

Original language	English
Pages (from-to)	213-216
Number of pages	4
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/0035-9203(90)90259-H
State	Published - Mar 1990
Externally published	Yes

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10.1016/0035-9203(90)90259-H

Cite this

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title = "Inhibition of Plasmodium falciparum growth by a synthetic iron chelator",

abstract = "The susceptibility of the chloroquine-resistant malaria parasite Plasmodium falciparum (FCR-3) to a pyridoxal-based iron chelator was tested. 10 μ m of the chelator 1 [n-ethoxycarbonylmethyl-pyridoxylidenium]-2-[2'-pyridyl] hydrazine bromide (code name L2-9) effectively inhibited growth in vitro of the parasites. Presaturation of the chelator with either ferric or ferrous iron partially blocked the inhibitory effect. Two hours' exposure of parasites to 20 L2-9 was sufficient to inhibit their growth irreversibly. Desferrioxamine blocked the inhibitory effect of L2-9. It is suggested that the chelator may be acting by generating free radicals in complexing intracellular iron.",

author = "Iheanacho, \{Eugene N.\} and Amram Samuni and Schelly Avramovici-Grisaru and Shalom Sarel and Spira, \{Dan T.\}",

year = "1990",

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doi = "10.1016/0035-9203(90)90259-H",

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AU - Iheanacho, Eugene N.

AU - Samuni, Amram

AU - Avramovici-Grisaru, Schelly

AU - Sarel, Shalom

AU - Spira, Dan T.

PY - 1990/3

Y1 - 1990/3

N2 - The susceptibility of the chloroquine-resistant malaria parasite Plasmodium falciparum (FCR-3) to a pyridoxal-based iron chelator was tested. 10 μ m of the chelator 1 [n-ethoxycarbonylmethyl-pyridoxylidenium]-2-[2'-pyridyl] hydrazine bromide (code name L2-9) effectively inhibited growth in vitro of the parasites. Presaturation of the chelator with either ferric or ferrous iron partially blocked the inhibitory effect. Two hours' exposure of parasites to 20 L2-9 was sufficient to inhibit their growth irreversibly. Desferrioxamine blocked the inhibitory effect of L2-9. It is suggested that the chelator may be acting by generating free radicals in complexing intracellular iron.

AB - The susceptibility of the chloroquine-resistant malaria parasite Plasmodium falciparum (FCR-3) to a pyridoxal-based iron chelator was tested. 10 μ m of the chelator 1 [n-ethoxycarbonylmethyl-pyridoxylidenium]-2-[2'-pyridyl] hydrazine bromide (code name L2-9) effectively inhibited growth in vitro of the parasites. Presaturation of the chelator with either ferric or ferrous iron partially blocked the inhibitory effect. Two hours' exposure of parasites to 20 L2-9 was sufficient to inhibit their growth irreversibly. Desferrioxamine blocked the inhibitory effect of L2-9. It is suggested that the chelator may be acting by generating free radicals in complexing intracellular iron.

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Inhibition of Plasmodium falciparum growth by a synthetic iron chelator

Abstract

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