Inhibition of the activity of glucosyltransferase from Streptococcus mutans by glycyrrhizin

M. N. Sela*, D. Steinberg, R. Segal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We have previously shown that the natural sweetener glycyrrhizin (glyc) inhibits in vitro adherence of Streptococcus mutans in the presence of sucrose. In order to further examine the mechanism of adherence inhibition, extracellular glucosyltransferase of S. mutans was obtained, and its ability to produce glucans from sucrose in the presence of glyc was tested. These results indicate that glyc inhibits bacterial adherence by affecting the activity of glucosyltransferase.

Original languageAmerican English
Pages (from-to)125-128
Number of pages4
JournalOral Microbiology and Immunology
Volume2
Issue number3
DOIs
StatePublished - Sep 1987
Externally publishedYes

Keywords

  • Streptococcus mutans
  • glucosyltransferase

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