Inhibition of the activity of glucosyltransferase from Streptococcus mutans by glycyrrhizin

M. N. Sela; D. Steinberg; R. Segal

doi:10.1111/j.1399-302X.1987.tb00275.x

Inhibition of the activity of glucosyltransferase from Streptococcus mutans by glycyrrhizin

M. N. Sela^*
, D. Steinberg
, R. Segal

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We have previously shown that the natural sweetener glycyrrhizin (glyc) inhibits in vitro adherence of Streptococcus mutans in the presence of sucrose. In order to further examine the mechanism of adherence inhibition, extracellular glucosyltransferase of S. mutans was obtained, and its ability to produce glucans from sucrose in the presence of glyc was tested. These results indicate that glyc inhibits bacterial adherence by affecting the activity of glucosyltransferase.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	Oral Microbiology and Immunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-302X.1987.tb00275.x
State	Published - Sep 1987

Keywords

Streptococcus mutans
glucosyltransferase

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10.1111/j.1399-302X.1987.tb00275.x

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abstract = "We have previously shown that the natural sweetener glycyrrhizin (glyc) inhibits in vitro adherence of Streptococcus mutans in the presence of sucrose. In order to further examine the mechanism of adherence inhibition, extracellular glucosyltransferase of S. mutans was obtained, and its ability to produce glucans from sucrose in the presence of glyc was tested. These results indicate that glyc inhibits bacterial adherence by affecting the activity of glucosyltransferase.",

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N2 - We have previously shown that the natural sweetener glycyrrhizin (glyc) inhibits in vitro adherence of Streptococcus mutans in the presence of sucrose. In order to further examine the mechanism of adherence inhibition, extracellular glucosyltransferase of S. mutans was obtained, and its ability to produce glucans from sucrose in the presence of glyc was tested. These results indicate that glyc inhibits bacterial adherence by affecting the activity of glucosyltransferase.

AB - We have previously shown that the natural sweetener glycyrrhizin (glyc) inhibits in vitro adherence of Streptococcus mutans in the presence of sucrose. In order to further examine the mechanism of adherence inhibition, extracellular glucosyltransferase of S. mutans was obtained, and its ability to produce glucans from sucrose in the presence of glyc was tested. These results indicate that glyc inhibits bacterial adherence by affecting the activity of glucosyltransferase.

KW - Streptococcus mutans

KW - glucosyltransferase

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Inhibition of the activity of glucosyltransferase from Streptococcus mutans by glycyrrhizin

Abstract

Keywords

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