TY - JOUR
T1 - Inhibition of vaccinia virus growth by the nucleoside analogue 1 β d ribofuranosyl 1,2,4 triazole 3 carboxamide (Virazole, Ribavirin)
AU - Katz, E.
AU - Margalith, E.
AU - Winer, B.
PY - 1976
Y1 - 1976
N2 - Virazole or Ribavirin (1 β (D) ribofuranosyl 1,2,4 triazole 3 carboxamide) inhibits the growth of vaccinia virus at a concentration of 50 μg/ml. Although vaccinia virus DNA and polypeptides are made to a certain extent in the presence of Virazole, the DNA fails to acquire resistance to deoxyribonuclease and virus particles are not formed. Reversibility of the antiviral effect occurs when the drug is washed out from the infected cultures or when guanosine at an equimolar concentration is added.
AB - Virazole or Ribavirin (1 β (D) ribofuranosyl 1,2,4 triazole 3 carboxamide) inhibits the growth of vaccinia virus at a concentration of 50 μg/ml. Although vaccinia virus DNA and polypeptides are made to a certain extent in the presence of Virazole, the DNA fails to acquire resistance to deoxyribonuclease and virus particles are not formed. Reversibility of the antiviral effect occurs when the drug is washed out from the infected cultures or when guanosine at an equimolar concentration is added.
UR - http://www.scopus.com/inward/record.url?scp=0017175223&partnerID=8YFLogxK
U2 - 10.1099/0022-1317-32-2-327
DO - 10.1099/0022-1317-32-2-327
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C2 - 1018177
AN - SCOPUS:0017175223
SN - 0022-1317
VL - 32
SP - 327
EP - 330
JO - Journal of General Virology
JF - Journal of General Virology
IS - 2
ER -