Inhibition of vaccinia virus growth by the nucleoside analogue 1 β d ribofuranosyl 1,2,4 triazole 3 carboxamide (Virazole, Ribavirin)

E. Katz; E. Margalith; B. Winer

doi:10.1099/0022-1317-32-2-327

Inhibition of vaccinia virus growth by the nucleoside analogue 1 β d ribofuranosyl 1,2,4 triazole 3 carboxamide (Virazole, Ribavirin)

E. Katz
, E. Margalith
, B. Winer

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Virazole or Ribavirin (1 β (D) ribofuranosyl 1,2,4 triazole 3 carboxamide) inhibits the growth of vaccinia virus at a concentration of 50 μg/ml. Although vaccinia virus DNA and polypeptides are made to a certain extent in the presence of Virazole, the DNA fails to acquire resistance to deoxyribonuclease and virus particles are not formed. Reversibility of the antiviral effect occurs when the drug is washed out from the infected cultures or when guanosine at an equimolar concentration is added.

Original language	English
Pages (from-to)	327-330
Number of pages	4
Journal	Journal of General Virology
Volume	32
Issue number	2
DOIs	https://doi.org/10.1099/0022-1317-32-2-327
State	Published - 1976

Access to Document

10.1099/0022-1317-32-2-327

Cite this

@article{0f7aac2f3f7f4a5f9d05e9c9612002fa,

title = "Inhibition of vaccinia virus growth by the nucleoside analogue 1 β d ribofuranosyl 1,2,4 triazole 3 carboxamide (Virazole, Ribavirin)",

abstract = "Virazole or Ribavirin (1 β (D) ribofuranosyl 1,2,4 triazole 3 carboxamide) inhibits the growth of vaccinia virus at a concentration of 50 μg/ml. Although vaccinia virus DNA and polypeptides are made to a certain extent in the presence of Virazole, the DNA fails to acquire resistance to deoxyribonuclease and virus particles are not formed. Reversibility of the antiviral effect occurs when the drug is washed out from the infected cultures or when guanosine at an equimolar concentration is added.",

author = "E. Katz and E. Margalith and B. Winer",

year = "1976",

doi = "10.1099/0022-1317-32-2-327",

language = "אנגלית",

volume = "32",

pages = "327--330",

journal = "Journal of General Virology",

issn = "0022-1317",

publisher = "Microbiology Society",

number = "2",

}

TY - JOUR

T1 - Inhibition of vaccinia virus growth by the nucleoside analogue 1 β d ribofuranosyl 1,2,4 triazole 3 carboxamide (Virazole, Ribavirin)

AU - Katz, E.

AU - Margalith, E.

AU - Winer, B.

PY - 1976

Y1 - 1976

N2 - Virazole or Ribavirin (1 β (D) ribofuranosyl 1,2,4 triazole 3 carboxamide) inhibits the growth of vaccinia virus at a concentration of 50 μg/ml. Although vaccinia virus DNA and polypeptides are made to a certain extent in the presence of Virazole, the DNA fails to acquire resistance to deoxyribonuclease and virus particles are not formed. Reversibility of the antiviral effect occurs when the drug is washed out from the infected cultures or when guanosine at an equimolar concentration is added.

AB - Virazole or Ribavirin (1 β (D) ribofuranosyl 1,2,4 triazole 3 carboxamide) inhibits the growth of vaccinia virus at a concentration of 50 μg/ml. Although vaccinia virus DNA and polypeptides are made to a certain extent in the presence of Virazole, the DNA fails to acquire resistance to deoxyribonuclease and virus particles are not formed. Reversibility of the antiviral effect occurs when the drug is washed out from the infected cultures or when guanosine at an equimolar concentration is added.

UR - https://www.scopus.com/pages/publications/0017175223

U2 - 10.1099/0022-1317-32-2-327

DO - 10.1099/0022-1317-32-2-327

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 1018177

AN - SCOPUS:0017175223

SN - 0022-1317

VL - 32

SP - 327

EP - 330

JO - Journal of General Virology

JF - Journal of General Virology

IS - 2

ER -

Inhibition of vaccinia virus growth by the nucleoside analogue 1 β d ribofuranosyl 1,2,4 triazole 3 carboxamide (Virazole, Ribavirin)

Abstract

Access to Document

Other files and links

Fingerprint

Cite this