Inhibitors of collagenase IV and cell adhesion reduce the invasive activity of malignant tumour cells.

R. Reich*, B. Stratford, K. Klein, G. R. Martin, R. A. Mueller, G. C. Fuller

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The invasive activities of some malignant cells appear to be activated by contact with laminin. This protein occurs solely in basement membranes and the binding of malignant cells to the surface of this extracellular matrix initiates the invasion process. Passage of the cells across basement membrane requires degradative activity and laminin induces the production of collagenase IV which lyses the collagen IV network. The motility of the cells is enhanced by chemo-attractants and by matrix molecules. Peptides that inhibit the binding of tumour cells to laminin, inhibitors of collagenase IV, and inhibitors of specific pathways of arachidonic acid metabolism prevent invasion as well as the metastasis of malignant cells and could be employed to stop the spread of cancer.

Original languageEnglish
Pages (from-to)193-210
Number of pages18
JournalCiba Foundation symposium
Volume141
StatePublished - 1988
Externally publishedYes

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