Inhibitory effect of lycopene on cataract development in galactosemic rats.

A. Pollack; Z. Madar; Z. Eisner; A. Nyska; P. Oren

Inhibitory effect of lycopene on cataract development in galactosemic rats.

A. Pollack^*
, Z. Madar
, Z. Eisner
, A. Nyska
, P. Oren

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

This study investigated the effect of antioxidants on cataract formation in galactosemic rats. Two antioxicants were compared: lycopene, a carotenoid derived from tomato, and butylated hydroxytoluene (BHT), a known antioxidant substance. The control group was fed with galactose 30%. The experimental groups received, in addition to galactose 30%, either lycopene 0.8% or BHT 0.2%. Cataractogenesis was evaluated by the incidence of cataract, grading of cataract, histology of the lenses, aldose reductase (AR) activity, protein levels, and reduced glutathione (GSH) contents in the lens. In both experiemtal groups: 1) the incidence and grading of cataract were lower, 2) the protein levels and GSH content were higher, and 3) the AR was decreased compared to the control group. In conclusion, "natural antioxidants" such as lycopene derived from tomato have a similar effect as BHT in delaying cataractogenesis in rats.

Original language	English
Pages (from-to)	31-36
Number of pages	6
Journal	Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)
Volume	19-20
State	Published - 1996
Externally published	Yes

Cite this

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title = "Inhibitory effect of lycopene on cataract development in galactosemic rats.",

abstract = "This study investigated the effect of antioxidants on cataract formation in galactosemic rats. Two antioxicants were compared: lycopene, a carotenoid derived from tomato, and butylated hydroxytoluene (BHT), a known antioxidant substance. The control group was fed with galactose 30\%. The experimental groups received, in addition to galactose 30\%, either lycopene 0.8\% or BHT 0.2\%. Cataractogenesis was evaluated by the incidence of cataract, grading of cataract, histology of the lenses, aldose reductase (AR) activity, protein levels, and reduced glutathione (GSH) contents in the lens. In both experiemtal groups: 1) the incidence and grading of cataract were lower, 2) the protein levels and GSH content were higher, and 3) the AR was decreased compared to the control group. In conclusion, {"}natural antioxidants{"} such as lycopene derived from tomato have a similar effect as BHT in delaying cataractogenesis in rats.",

author = "A. Pollack and Z. Madar and Z. Eisner and A. Nyska and P. Oren",

year = "1996",

language = "אנגלית",

volume = "19-20",

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journal = "Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)",

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T1 - Inhibitory effect of lycopene on cataract development in galactosemic rats.

AU - Pollack, A.

AU - Madar, Z.

AU - Eisner, Z.

AU - Nyska, A.

AU - Oren, P.

PY - 1996

Y1 - 1996

N2 - This study investigated the effect of antioxidants on cataract formation in galactosemic rats. Two antioxicants were compared: lycopene, a carotenoid derived from tomato, and butylated hydroxytoluene (BHT), a known antioxidant substance. The control group was fed with galactose 30%. The experimental groups received, in addition to galactose 30%, either lycopene 0.8% or BHT 0.2%. Cataractogenesis was evaluated by the incidence of cataract, grading of cataract, histology of the lenses, aldose reductase (AR) activity, protein levels, and reduced glutathione (GSH) contents in the lens. In both experiemtal groups: 1) the incidence and grading of cataract were lower, 2) the protein levels and GSH content were higher, and 3) the AR was decreased compared to the control group. In conclusion, "natural antioxidants" such as lycopene derived from tomato have a similar effect as BHT in delaying cataractogenesis in rats.

AB - This study investigated the effect of antioxidants on cataract formation in galactosemic rats. Two antioxicants were compared: lycopene, a carotenoid derived from tomato, and butylated hydroxytoluene (BHT), a known antioxidant substance. The control group was fed with galactose 30%. The experimental groups received, in addition to galactose 30%, either lycopene 0.8% or BHT 0.2%. Cataractogenesis was evaluated by the incidence of cataract, grading of cataract, histology of the lenses, aldose reductase (AR) activity, protein levels, and reduced glutathione (GSH) contents in the lens. In both experiemtal groups: 1) the incidence and grading of cataract were lower, 2) the protein levels and GSH content were higher, and 3) the AR was decreased compared to the control group. In conclusion, "natural antioxidants" such as lycopene derived from tomato have a similar effect as BHT in delaying cataractogenesis in rats.

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JO - Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)

JF - Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985)

ER -

Inhibitory effect of lycopene on cataract development in galactosemic rats.

Abstract

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