Ini1 is essential for embryonic development and tumor suppression

Cynthia J. Guidi*, Stephen N. Jones, Anthony N. Imbalzano, C. J. Guidi*, A. T. Sands, B. P. Zambrowicz, T. K. Turner, D. A. Demers, W. Webster, T. W. Smith, A. N. Imbalzano, S. N. Jones, A. Klochendler-Yeivin, L. Fiette, J. Barra, C. Muchardt, C. Babinet, M. Yaniv, C. W.M. Roberts, S. A. GalushaM. E. McMenamin, C. D.M. Fletcher, S. H. Orkin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The three papers reviewed here report data that show Ini1 plays an essential role in murine development; Inil-null embryos die between 3.5 and 5.5 days post fertilization. Additionally, Ini1 functions as a tumor suppressor in the murine model. Ini1-heterozygous mice present with a range of tumors with variable penetrance.

Original languageAmerican English
Pages (from-to)751-756
Number of pages6
Issue number13
StatePublished - 2001
Externally publishedYes


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