Ini1 is essential for embryonic development and tumor suppression

Cynthia J. Guidi; Stephen N. Jones; Anthony N. Imbalzano; C. J. Guidi; A. T. Sands; B. P. Zambrowicz; T. K. Turner; D. A. Demers; W. Webster; T. W. Smith; A. N. Imbalzano; S. N. Jones; A. Klochendler-Yeivin; L. Fiette; J. Barra; C. Muchardt; C. Babinet; M. Yaniv; C. W.M. Roberts; S. A. Galusha; M. E. McMenamin; C. D.M. Fletcher; S. H. Orkin

Ini1 is essential for embryonic development and tumor suppression

Cynthia J. Guidi^*
, Stephen N. Jones
, Anthony N. Imbalzano
, C. J. Guidi^*
, A. T. Sands
, B. P. Zambrowicz
, T. K. Turner
, D. A. Demers
, W. Webster
, T. W. Smith
, A. N. Imbalzano
, S. N. Jones
, A. Klochendler-Yeivin
, L. Fiette
, J. Barra
, C. Muchardt
, C. Babinet
, M. Yaniv
, C. W.M. Roberts
, S. A. Galusha

M. E. McMenamin, C. D.M. Fletcher, S. H. Orkin

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

The three papers reviewed here report data that show Ini1 plays an essential role in murine development; Inil-null embryos die between 3.5 and 5.5 days post fertilization. Additionally, Ini1 functions as a tumor suppressor in the murine model. Ini1-heterozygous mice present with a range of tumors with variable penetrance.

Original language	English
Pages (from-to)	751-756
Number of pages	6
Journal	Chemtracts
Volume	14
Issue number	13
State	Published - 2001
Externally published	Yes

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Guidi, C. J., Jones, S. N., Imbalzano, A. N., Guidi, C. J., Sands, A. T., Zambrowicz, B. P., Turner, T. K., Demers, D. A., Webster, W., Smith, T. W., Imbalzano, A. N., Jones, S. N., Klochendler-Yeivin, A., Fiette, L., Barra, J., Muchardt, C., Babinet, C., Yaniv, M., Roberts, C. W. M., ... Orkin, S. H. (2001). Ini1 is essential for embryonic development and tumor suppression. Chemtracts, 14(13), 751-756.

@article{7a5cc419977f42ceb72df53a8758ee2f,

title = "Ini1 is essential for embryonic development and tumor suppression",

abstract = "The three papers reviewed here report data that show Ini1 plays an essential role in murine development; Inil-null embryos die between 3.5 and 5.5 days post fertilization. Additionally, Ini1 functions as a tumor suppressor in the murine model. Ini1-heterozygous mice present with a range of tumors with variable penetrance.",

author = "Guidi, \{Cynthia J.\} and Jones, \{Stephen N.\} and Imbalzano, \{Anthony N.\} and Guidi, \{C. J.\} and Sands, \{A. T.\} and Zambrowicz, \{B. P.\} and Turner, \{T. K.\} and Demers, \{D. A.\} and W. Webster and Smith, \{T. W.\} and Imbalzano, \{A. N.\} and Jones, \{S. N.\} and A. Klochendler-Yeivin and L. Fiette and J. Barra and C. Muchardt and C. Babinet and M. Yaniv and Roberts, \{C. W.M.\} and Galusha, \{S. A.\} and McMenamin, \{M. E.\} and Fletcher, \{C. D.M.\} and Orkin, \{S. H.\}",

year = "2001",

language = "אנגלית",

volume = "14",

pages = "751--756",

journal = "Chemtracts",

issn = "1431-9268",

publisher = "Data Trace Publishing Co.",

number = "13",

}

Guidi, CJ, Jones, SN, Imbalzano, AN, Guidi, CJ, Sands, AT, Zambrowicz, BP, Turner, TK, Demers, DA, Webster, W, Smith, TW, Imbalzano, AN, Jones, SN, Klochendler-Yeivin, A, Fiette, L, Barra, J, Muchardt, C, Babinet, C, Yaniv, M, Roberts, CWM, Galusha, SA, McMenamin, ME, Fletcher, CDM & Orkin, SH 2001, 'Ini1 is essential for embryonic development and tumor suppression', Chemtracts, vol. 14, no. 13, pp. 751-756.

TY - JOUR

T1 - Ini1 is essential for embryonic development and tumor suppression

AU - Guidi, Cynthia J.

AU - Jones, Stephen N.

AU - Imbalzano, Anthony N.

AU - Guidi, C. J.

AU - Sands, A. T.

AU - Zambrowicz, B. P.

AU - Turner, T. K.

AU - Demers, D. A.

AU - Webster, W.

AU - Smith, T. W.

AU - Imbalzano, A. N.

AU - Jones, S. N.

AU - Klochendler-Yeivin, A.

AU - Fiette, L.

AU - Barra, J.

AU - Muchardt, C.

AU - Babinet, C.

AU - Yaniv, M.

AU - Roberts, C. W.M.

AU - Galusha, S. A.

AU - McMenamin, M. E.

AU - Fletcher, C. D.M.

AU - Orkin, S. H.

PY - 2001

Y1 - 2001

N2 - The three papers reviewed here report data that show Ini1 plays an essential role in murine development; Inil-null embryos die between 3.5 and 5.5 days post fertilization. Additionally, Ini1 functions as a tumor suppressor in the murine model. Ini1-heterozygous mice present with a range of tumors with variable penetrance.

AB - The three papers reviewed here report data that show Ini1 plays an essential role in murine development; Inil-null embryos die between 3.5 and 5.5 days post fertilization. Additionally, Ini1 functions as a tumor suppressor in the murine model. Ini1-heterozygous mice present with a range of tumors with variable penetrance.

UR - https://www.scopus.com/pages/publications/0035716942

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AN - SCOPUS:0035716942

SN - 1431-9268

VL - 14

SP - 751

EP - 756

JO - Chemtracts

JF - Chemtracts

IS - 13

ER -

Ini1 is essential for embryonic development and tumor suppression

Abstract

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