Injections of the neuroprotective peptide NAP to newborn mice attenuate head-injury-related dysfunction in adults

Roy Zaltzman; Sara M. Beni; Eliezer Giladi; Albert Pinhasov; Ruth A. Steingart; Jacob Romano; Esther Shohami; Illana Gozes

doi:10.1097/00001756-200303030-00037

Injections of the neuroprotective peptide NAP to newborn mice attenuate head-injury-related dysfunction in adults

Roy Zaltzman, Sara M. Beni, Eliezer Giladi, Albert Pinhasov, Ruth A. Steingart, Jacob Romano, Esther Shohami, Illana Gozes^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The prophylactic neuroprotective effects of NAP, a femtomolaracting neuroprotective peptide were tested in a mouse model of head trauma. NAP was injected for the first 3 weeks of life and head injury was initiated at 4 months. After trauma, mice were tested for their performance by evaluating damaged motor ability, balance and alertness. Comparison of the performance 1 h and 1 week after injury indicated that NAP treatment resulted in faster and enhanced recovery. In a 5-day Morris water maze test with mice suffering moderate to severe injuries, only the NAP-treated group learned to find the hidden platform in the maze. Furthermore, NAP treatment resulted in decreased mRNA expression of the inflammation marker, Mac-1. Thus, a potentially new prophylactic treatment against neurodegeneration is suggested.

Original language	English
Pages (from-to)	481-484
Number of pages	4
Journal	NeuroReport
Volume	14
Issue number	3
DOIs	https://doi.org/10.1097/00001756-200303030-00037
State	Published - 3 Mar 2003

Keywords

Inflammation
Peptides
Traumatic brain injury
Water maze

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10.1097/00001756-200303030-00037

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abstract = "The prophylactic neuroprotective effects of NAP, a femtomolaracting neuroprotective peptide were tested in a mouse model of head trauma. NAP was injected for the first 3 weeks of life and head injury was initiated at 4 months. After trauma, mice were tested for their performance by evaluating damaged motor ability, balance and alertness. Comparison of the performance 1 h and 1 week after injury indicated that NAP treatment resulted in faster and enhanced recovery. In a 5-day Morris water maze test with mice suffering moderate to severe injuries, only the NAP-treated group learned to find the hidden platform in the maze. Furthermore, NAP treatment resulted in decreased mRNA expression of the inflammation marker, Mac-1. Thus, a potentially new prophylactic treatment against neurodegeneration is suggested.",

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AU - Pinhasov, Albert

AU - Steingart, Ruth A.

AU - Romano, Jacob

AU - Shohami, Esther

AU - Gozes, Illana

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Injections of the neuroprotective peptide NAP to newborn mice attenuate head-injury-related dysfunction in adults

Abstract

Keywords

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