Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus)

Tamar Ravins Yaish; Noa Eshkol Noy; Rony Kalman; Jing Guang; Halen Baker Erdman; Orilia Ben-Yishay Nizri; Shimon Firman; Xiaowei Liu; Marc Deffains; Uri Werner-Reiss; Galith Abourbeh; Zvi Israel; Hagai Bergman; Lily Iskhakova

doi:10.1177/00236772241302576

Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus)

Tamar Ravins Yaish, Noa Eshkol Noy, Rony Kalman, Jing Guang, Halen Baker Erdman, Orilia Ben-Yishay Nizri, Shimon Firman, Xiaowei Liu, Marc Deffains, Uri Werner-Reiss, Galith Abourbeh, Zvi Israel, Hagai Bergman, Lily Iskhakova

Edmond & Lily Safra Center for Brain Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The MPTP-animal model of Parkinson’s disease has significantly advanced our understanding of Parkinson’s disease and the dopaminergic system, helping to establish disease mechanisms and develop therapeutic targets. The non-human primate (NHP) MPTP model is particularly valuable for replicating core Parkinson’s disease motor symptoms, anatomical changes and electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading to euthanasia. While some post-MPTP primates recovered spontaneously, purposefully induced recovery was considered unattainable. Our team developed a novel intensive care protocol (NICP) promoting complete recovery from MPTP-induced severe parkinsonism in NHPs. NICP provides therapeutic, nutritional and social support, enabling behavioral recovery and subsequent retirement to a primate sanctuary. This innovation enhances animal welfare and opens new prospects for veterinary care, emphasizing the need to explore recovery mechanisms for other chronic conditions induced for research.

Original language	English
Journal	Laboratory Animals
DOIs	https://doi.org/10.1177/00236772241302576
State	Accepted/In press - 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

Keywords

Alternatives
animal use
disease model
ethics and welfare
organisms and models
primate
refinement

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Ravins Yaish, T., Eshkol Noy, N., Kalman, R., Guang, J., Baker Erdman, H., Ben-Yishay Nizri, O., Firman, S., Liu, X., Deffains, M., Werner-Reiss, U., Abourbeh, G., Israel, Z., Bergman, H., & Iskhakova, L. (Accepted/In press). Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus). Laboratory Animals. https://doi.org/10.1177/00236772241302576

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title = "Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus)",

abstract = "The MPTP-animal model of Parkinson{\textquoteright}s disease has significantly advanced our understanding of Parkinson{\textquoteright}s disease and the dopaminergic system, helping to establish disease mechanisms and develop therapeutic targets. The non-human primate (NHP) MPTP model is particularly valuable for replicating core Parkinson{\textquoteright}s disease motor symptoms, anatomical changes and electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading to euthanasia. While some post-MPTP primates recovered spontaneously, purposefully induced recovery was considered unattainable. Our team developed a novel intensive care protocol (NICP) promoting complete recovery from MPTP-induced severe parkinsonism in NHPs. NICP provides therapeutic, nutritional and social support, enabling behavioral recovery and subsequent retirement to a primate sanctuary. This innovation enhances animal welfare and opens new prospects for veterinary care, emphasizing the need to explore recovery mechanisms for other chronic conditions induced for research.",

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author = "{Ravins Yaish}, Tamar and {Eshkol Noy}, Noa and Rony Kalman and Jing Guang and {Baker Erdman}, Halen and {Ben-Yishay Nizri}, Orilia and Shimon Firman and Xiaowei Liu and Marc Deffains and Uri Werner-Reiss and Galith Abourbeh and Zvi Israel and Hagai Bergman and Lily Iskhakova",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

doi = "10.1177/00236772241302576",

language = "אנגלית",

journal = "Laboratory Animals",

issn = "0023-6772",

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Ravins Yaish, T, Eshkol Noy, N, Kalman, R, Guang, J, Baker Erdman, H, Ben-Yishay Nizri, O, Firman, S, Liu, X, Deffains, M, Werner-Reiss, U, Abourbeh, G, Israel, Z, Bergman, H & Iskhakova, L 2025, 'Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus)', Laboratory Animals. https://doi.org/10.1177/00236772241302576

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AU - Eshkol Noy, Noa

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AU - Liu, Xiaowei

AU - Deffains, Marc

AU - Werner-Reiss, Uri

AU - Abourbeh, Galith

AU - Israel, Zvi

AU - Bergman, Hagai

AU - Iskhakova, Lily

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Innovative care protocol successfully rehabilitates non-human primates after MPTP-induced parkinsonism: Preliminary evidence from a restricted cohort of African Green Monkeys (Chlorocebus sabaeus)

Abstract

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Keywords

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