Inositol monophosphatase activity in brain and lymphocyte-derived ceii lines of bipolar patients

Galit Shaltiel; Alon Shamir; Lubov Nemanov; Yuri Yaroslavsky; Boris Nemets; Richard P. Ebstein; Robert H. Belmaker; Galila Agam

doi:10.3109/15622970109027499

Inositol monophosphatase activity in brain and lymphocyte-derived ceii lines of bipolar patients

Galit Shaltiel
, Alon Shamir
, Lubov Nemanov
, Yuri Yaroslavsky
, Boris Nemets
, Richard P. Ebstein
, Robert H. Belmaker
, Galila Agam^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: Inositol monophosphatase (IMPase) activity was reported to be low in lymphocyte-derived cell lines of bipolar patients. Methods: IMPase activity was measured spectrophotometrically as inorganic phosphate liberated from inositol-1-phosphate. Results: The previously reported reduction was replicated in a new, small group of bipolar patients. The reduction is not present in cell lines of unipolar or schizophrenic patients. IMPase activity in postmortem frontal and occipital cortical samples of unipolar, bipolar and schizophrenic patients was not different from controls. Conclusions: A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene.

Original language	English
Pages (from-to)	95-98
Number of pages	4
Journal	World Journal of Biological Psychiatry
Volume	2
Issue number	2
DOIs	https://doi.org/10.3109/15622970109027499
State	Published - 2001
Externally published	Yes

Keywords

bipolar disorder
enzyme activity
inositol monophosphatase (IMPase)
lymphcytederived cell lines
postmortem brain

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10.3109/15622970109027499

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title = "Inositol monophosphatase activity in brain and lymphocyte-derived ceii lines of bipolar patients",

abstract = "Background: Inositol monophosphatase (IMPase) activity was reported to be low in lymphocyte-derived cell lines of bipolar patients. Methods: IMPase activity was measured spectrophotometrically as inorganic phosphate liberated from inositol-1-phosphate. Results: The previously reported reduction was replicated in a new, small group of bipolar patients. The reduction is not present in cell lines of unipolar or schizophrenic patients. IMPase activity in postmortem frontal and occipital cortical samples of unipolar, bipolar and schizophrenic patients was not different from controls. Conclusions: A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene.",

keywords = "bipolar disorder, enzyme activity, inositol monophosphatase (IMPase), lymphcytederived cell lines, postmortem brain",

author = "Galit Shaltiel and Alon Shamir and Lubov Nemanov and Yuri Yaroslavsky and Boris Nemets and Ebstein, \{Richard P.\} and Belmaker, \{Robert H.\} and Galila Agam",

year = "2001",

doi = "10.3109/15622970109027499",

language = "אנגלית",

volume = "2",

pages = "95--98",

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T1 - Inositol monophosphatase activity in brain and lymphocyte-derived ceii lines of bipolar patients

AU - Shaltiel, Galit

AU - Shamir, Alon

AU - Nemanov, Lubov

AU - Yaroslavsky, Yuri

AU - Nemets, Boris

AU - Ebstein, Richard P.

AU - Belmaker, Robert H.

AU - Agam, Galila

PY - 2001

Y1 - 2001

N2 - Background: Inositol monophosphatase (IMPase) activity was reported to be low in lymphocyte-derived cell lines of bipolar patients. Methods: IMPase activity was measured spectrophotometrically as inorganic phosphate liberated from inositol-1-phosphate. Results: The previously reported reduction was replicated in a new, small group of bipolar patients. The reduction is not present in cell lines of unipolar or schizophrenic patients. IMPase activity in postmortem frontal and occipital cortical samples of unipolar, bipolar and schizophrenic patients was not different from controls. Conclusions: A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene.

AB - Background: Inositol monophosphatase (IMPase) activity was reported to be low in lymphocyte-derived cell lines of bipolar patients. Methods: IMPase activity was measured spectrophotometrically as inorganic phosphate liberated from inositol-1-phosphate. Results: The previously reported reduction was replicated in a new, small group of bipolar patients. The reduction is not present in cell lines of unipolar or schizophrenic patients. IMPase activity in postmortem frontal and occipital cortical samples of unipolar, bipolar and schizophrenic patients was not different from controls. Conclusions: A reduction in lymphocyte-derived IMPase activity without a parallel reduction in cortical IMPase activity could be due to the fact that most leukocyte IMPase activity is the product of the IMPA-2 gene.

KW - bipolar disorder

KW - enzyme activity

KW - inositol monophosphatase (IMPase)

KW - lymphcytederived cell lines

KW - postmortem brain

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Inositol monophosphatase activity in brain and lymphocyte-derived ceii lines of bipolar patients

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