Insights on Spirocerca lupi, the Carcinogenic Dog Nematode

Alicia Rojas, Eran Dvir, Gad Baneth*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Spirocerca lupi is a nematode transmitted by dung beetles that infects domestic and wild canids in tropical and subtropical regions and is associated with neoplasia. It produces a distinctive pathology with the formation of esophageal nodules classified as inflammatory, preneoplastic, or neoplastic with metastasis to distant organs. Aberrant central nervous system migration of this nematode is also responsible for severe neurological manifestations. Reports of spirocercosis have increased over the last two decades showing spread of this canine helminth in five continents. S. lupi from different geographical locations is genetically distinct with two genotypes, genotype I from Africa, Asia, and Australia, and genotype II from Europe, and recently separated from Spirocerca vulpis, a new species described in red foxes from Europe.

Original languageAmerican English
Pages (from-to)52-63
Number of pages12
JournalTrends in Parasitology
Issue number1
StatePublished - Jan 2020

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd


  • Spirocerca lupi
  • dogs
  • nematode
  • spirocercosis


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