IntAct: An open source molecular interaction database

Henning Hermjakob; Luisa Montecchi-Palazzi; Chris Lewington; Sugath Mudali; Samuel Kerrien; Sandra Orchard; Martin Vingron; Bernd Roechert; Peter Roepstorff; Alfonso Valencia; Hanah Margalit; John Armstrong; Amos Bairoch; Gianni Cesareni; David Sherman; Rolf Apweiler

IntAct: An open source molecular interaction database

Henning Hermjakob^*, Luisa Montecchi-Palazzi, Chris Lewington, Sugath Mudali, Samuel Kerrien, Sandra Orchard, Martin Vingron, Bernd Roechert, Peter Roepstorff, Alfonso Valencia, Hanah Margalit, John Armstrong, Amos Bairoch, Gianni Cesareni, David Sherman, Rolf Apweiler

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

805 Scopus citations

Abstract

IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotations of the interacting proteins. A web service allows direct computational access to retrieve interaction networks in XML format. IntAct currently contains ∼2200 binary and complex interactions imported from the literature and curated in collaboration with the Swiss-Prot team, making intensive use of controlled vocabularies to ensure data consistency. All IntAct software, data and controlled vocabularies are available at http://www.ebi.ac.uk/intact.

Original language	English
Pages (from-to)	D452-D455
Journal	Nucleic Acids Research
Volume	32
Issue number	DATABASE ISS.
State	Published - 1 Jan 2004

Cite this

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AU - Kerrien, Samuel

AU - Orchard, Sandra

AU - Vingron, Martin

AU - Roechert, Bernd

AU - Roepstorff, Peter

AU - Valencia, Alfonso

AU - Margalit, Hanah

AU - Armstrong, John

AU - Bairoch, Amos

AU - Cesareni, Gianni

AU - Sherman, David

AU - Apweiler, Rolf

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IntAct: An open source molecular interaction database

Abstract

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