Integrated nanoparticle-biomolecule hybrid systems: Synthesis, properties, and applications

Eugenii Katz, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2437 Scopus citations

Abstract

Nanomaterials, such as metal or semiconductor nanoparticles and nanorods, exhibit similar dimensions to those of biomolecules, such as proteins (enzymes, antigens, antibodies) or DNA. The integration of nanoparticles, which exhibit unique electronic, photonic, and catalytic properties, with biomaterials, which display unique recognition, catalytic, and inhibition properties, yields novel hybrid nanobiomaterials of synergetic properties and functions. This review describes recent advances in the synthesis of biomoleculenanoparticle/nanorod hybrid systems and the application of such assemblies in the generation of 2D and 3D ordered structures in solutions and on surfaces. Particular emphasis is directed to the use of biomolecule-nanoparticle (metallic or semiconductive) assemblies for bioanalytical applications and for the fabrication of bioelectronic devices.

Original languageEnglish
Pages (from-to)6042-6108
Number of pages67
JournalAngewandte Chemie - International Edition
Volume43
Issue number45
DOIs
StatePublished - 19 Nov 2004

Keywords

  • Biosensors
  • Nanobiotechnology
  • Nanoelectronics
  • Nanoparticles

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