TY - JOUR
T1 - Intellectual property and chirality of drugs
AU - Agranat, Israel
AU - Caner, Hava
PY - 1999/7/1
Y1 - 1999/7/1
N2 - Chirality has emerged as a key issue in drug design, discovery and development. Chiral switches are drugs that are already approved and claimed as racemates but that have been redeveloped as single enantiomers. The legal state of the art of patentability of chiral switches, as derived from US and European precedents, is reviewed. The issues of intellectual property in the pending chiral switches of the blockbuster drugs ibuprofen, fluoxetine and omeprazole are analysed. Copyright (C) 1999 Elsevier Science Ltd.
AB - Chirality has emerged as a key issue in drug design, discovery and development. Chiral switches are drugs that are already approved and claimed as racemates but that have been redeveloped as single enantiomers. The legal state of the art of patentability of chiral switches, as derived from US and European precedents, is reviewed. The issues of intellectual property in the pending chiral switches of the blockbuster drugs ibuprofen, fluoxetine and omeprazole are analysed. Copyright (C) 1999 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0033167950&partnerID=8YFLogxK
U2 - 10.1016/S1359-6446(99)01363-X
DO - 10.1016/S1359-6446(99)01363-X
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AN - SCOPUS:0033167950
SN - 1359-6446
VL - 4
SP - 313
EP - 321
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 7
ER -