Interaction of Enteropathogenic Escherichia coli with Host Epithelial Cells

I. Nisan, C. Wolff, E. Hanski, I. Rosenshine*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Enteropathogenic Escherichia coli (EPEC) causes severe diarrhea in young children. Upon infection, EPEC induces the assembly of highly organized pedestal-like actin structures in host epithelial cells. All the EPEC genes that are involved in inducing formation of actin pedestals are located in a unique 35 kbp chromosomal pathogenicity island, termed LEE. These genes include the sep genes that encode components of type III protein secretion system, and genes that encode proteins secreted by this system, the esp genes. This protein secretion system is activated upon contact with the host cell, resulting in increased secretion of Esp proteins. Some of these Esp proteins form the translocation apparatus while others are translocated into the cytoplasm of the host cell. Concerted activity of the LEE genes including the eae, esp and the sep genes is needed to trigger signal transduction in the host cell which results in formation of an actin pedestal.

Original languageAmerican English
Pages (from-to)247-252
Number of pages6
JournalFolia Microbiologica
Issue number3
StatePublished - 1998

Bibliographical note

Funding Information:
Work at IR laboratory was supported by grants from the Israeh Academy of Sctence, the Israel-Untted Foundatton, and the lsraeh Mmtstry of Health


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