TY - JOUR
T1 - Interaction of herpes simplex virus with human cell lines at various stages of lymphoid differentiation
AU - Katz, Ehud
AU - Mitrani-Rosenbaum, Stella
AU - Margalith, Eva
AU - Ben-Bassat, Hannah
PY - 1981
Y1 - 1981
N2 - The growth of herpes simplex virus (HSV) type 1 in human lymphoid cell lines, arrested at various stages of differentiation, was studied. The synthesis of viral DNA and antigens and the production of infectious virus were followed in null, B and T leukemia-lymphoma cell lines. It was found that while ‘nondifferentiated’ null cells and cells differentiating along the B pathway, even at very early stages of differentiation, supported HSV growth, cell lines of T origin at all stages of differentiation were generally nonpermissive. The failure of T cells to support the growth of HSV did not result from inefficient adsorption to the host cell. However, viral DNA synthesis was not detected, and a significant reduction in the ability to synthesize HSV antigens was observed. It is suggested that the block in the growth cycle of the virus occurs at a stage after adsorption of the virion to the cells, but prior to synthesis of its DNA and proteins.
AB - The growth of herpes simplex virus (HSV) type 1 in human lymphoid cell lines, arrested at various stages of differentiation, was studied. The synthesis of viral DNA and antigens and the production of infectious virus were followed in null, B and T leukemia-lymphoma cell lines. It was found that while ‘nondifferentiated’ null cells and cells differentiating along the B pathway, even at very early stages of differentiation, supported HSV growth, cell lines of T origin at all stages of differentiation were generally nonpermissive. The failure of T cells to support the growth of HSV did not result from inefficient adsorption to the host cell. However, viral DNA synthesis was not detected, and a significant reduction in the ability to synthesize HSV antigens was observed. It is suggested that the block in the growth cycle of the virus occurs at a stage after adsorption of the virion to the cells, but prior to synthesis of its DNA and proteins.
KW - Herpes simplex virus
KW - Lymphoid differentiation
KW - Lymphoid lines
UR - http://www.scopus.com/inward/record.url?scp=0019835894&partnerID=8YFLogxK
U2 - 10.1159/000149245
DO - 10.1159/000149245
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 6276325
AN - SCOPUS:0019835894
SN - 0300-5526
VL - 16
SP - 33
EP - 42
JO - Intervirology
JF - Intervirology
IS - 1
ER -