Interaction of herpes simplex virus with human cell lines at various stages of lymphoid differentiation

Ehud Katz, Stella Mitrani-Rosenbaum, Eva Margalith, Hannah Ben-Bassat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The growth of herpes simplex virus (HSV) type 1 in human lymphoid cell lines, arrested at various stages of differentiation, was studied. The synthesis of viral DNA and antigens and the production of infectious virus were followed in null, B and T leukemia-lymphoma cell lines. It was found that while ‘nondifferentiated’ null cells and cells differentiating along the B pathway, even at very early stages of differentiation, supported HSV growth, cell lines of T origin at all stages of differentiation were generally nonpermissive. The failure of T cells to support the growth of HSV did not result from inefficient adsorption to the host cell. However, viral DNA synthesis was not detected, and a significant reduction in the ability to synthesize HSV antigens was observed. It is suggested that the block in the growth cycle of the virus occurs at a stage after adsorption of the virion to the cells, but prior to synthesis of its DNA and proteins.

Original languageEnglish
Pages (from-to)33-42
Number of pages10
JournalIntervirology
Volume16
Issue number1
DOIs
StatePublished - 1981

Keywords

  • Herpes simplex virus
  • Lymphoid differentiation
  • Lymphoid lines

Fingerprint

Dive into the research topics of 'Interaction of herpes simplex virus with human cell lines at various stages of lymphoid differentiation'. Together they form a unique fingerprint.

Cite this