Interactions between γδT cells and neutrophils in cancer: knowns and unknowns

Jianlei Hao*, Zvi Granot*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The tumor microenvironment provides a unique opportunity to gain insight into the relationship and crosstalk between different cell types. In this context, little is known about the interaction between γδT cells and neutrophils, which are innate immune cells abundant in the tumor microenvironment. Interestingly, both γδT cells and neutrophils are heterogeneous, may play diverse regulatory roles, and have been shown to have both protumor and antitumor functions. In this editorial, we discuss recent advances in the understanding of interplay between γδT cells and neutrophils in cancer and provide insights and future directions highlighting the role these interactions may play in cancer.

Original languageEnglish
Pages (from-to)993-995
Number of pages3
JournalJournal of Leukocyte Biology
Volume115
Issue number6
DOIs
StatePublished - Jun 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site - for further information please contact [email protected].

Keywords

  • neutrophils
  • tumor
  • γδT cells

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