Abstract
Protein-protein interactions (PPI) are essential in every step of the HIV replication cycle. Mapping the interactions between viral and host proteins is a fundamental target for the design and development of new therapeutics. In this review, we focus on rational development of anti-HIV-1 peptides based on mapping viral-host and viral-viral protein interactions all across the HIV-1 replication cycle. We also discuss the mechanism of action, specificity and stability of these peptides, which are designed to inhibit PPI. Some of these peptides are excellent tools to study the mechanisms of PPI in HIV-1 replication cycle and for the development of anti-HIV-1 drug leads that modulate PPI.
Original language | English |
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Pages (from-to) | 1055-1077 |
Number of pages | 23 |
Journal | Future Medicinal Chemistry |
Volume | 7 |
Issue number | 8 |
DOIs | |
State | Published - 1 Jun 2015 |
Bibliographical note
Publisher Copyright:© 2015 Future Science Ltd.