Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides

Koushik Chandra, Michal Maes, Assaf Friedler*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Protein-protein interactions (PPI) are essential in every step of the HIV replication cycle. Mapping the interactions between viral and host proteins is a fundamental target for the design and development of new therapeutics. In this review, we focus on rational development of anti-HIV-1 peptides based on mapping viral-host and viral-viral protein interactions all across the HIV-1 replication cycle. We also discuss the mechanism of action, specificity and stability of these peptides, which are designed to inhibit PPI. Some of these peptides are excellent tools to study the mechanisms of PPI in HIV-1 replication cycle and for the development of anti-HIV-1 drug leads that modulate PPI.

Original languageAmerican English
Pages (from-to)1055-1077
Number of pages23
JournalFuture Medicinal Chemistry
Issue number8
StatePublished - 1 Jun 2015

Bibliographical note

Publisher Copyright:
© 2015 Future Science Ltd.


Dive into the research topics of 'Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides'. Together they form a unique fingerprint.

Cite this